Effect of Hydroethanolic Extract of Rubus fruticosus on Neuropathic Pain in Wistar Diabetic Rats

نویسندگان

  • Abdolkarim Hosseini Department of Physiology, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran
  • Ali Gomar Department of Biology, Science & Research Institute, Islamic Azad University, Tehran, Iran ; [email protected]
  • Mojtaba Gomar Student of Surgical technology, Faculty of Para medicine, Aja University of Medical Sciences, Tehran, Iran
  • Naser Mirazi Department of Biology, Faculty of Basic Sciences, Bu-Ali Sina University, Hamadan, Iran
چکیده مقاله:

Background: Diabetes mellitus is the most common metabolic disorder with many complications such as neuropathic pain which relief from it is a dilemma. Objectives: To investigate the effect of hydroethanolic extract of Rubus fruticosus on neuropathic pain in diabetic rats. Materials and Methods: In this experimental case &ndash;control study, forty eight male Wistar rats (250&plusmn;20 g) were divided randomly to non-diabetic and diabetic groups. Streptozotocin (60 mg/kg, intra-peritoneal) was used to induce experimental diabetes. Each group was divided into three groups: receiving orally normal saline, 100 and 200 mg/kg doses of Rubus fruticosus extract for 30 days. At the end the rats were subjected to Tail-Flick test. The data were analyzed by one-way and two-way ANOVA followed by Tukey&rsquo;s test in SPSS 21. Results: In a paired comparison, all diabetic groups had shorter latency of tail-flicking time (p < 0.01) and lower pain tolerance threshold. Also among diabetic rats, significant differences existed between saline group and group receiving the extract at a dose of 100 mg/Kg (p < 0.01), between saline group and the group receiving the extract at a dose of 200 mg/Kg (p < 0.001) and also between the groups receiving extract at two different doses (p < 0.001). But, only diabetic group receiving the extract at a dose of 200 mg/Kg showed positive significant difference with non-diabetic control group (p < 0.01). Conclusions: The hydroethanolic extract of Rubus fruticosus can heighten the pain tolerance threshold and reduce the neuropathic pain induced by diabetes mellitus.

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effect of hydroethanolic extract of rubus fruticosus on neuropathic pain in wistar diabetic rats

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عنوان ژورنال

دوره 1  شماره 1

صفحات  27- 34

تاریخ انتشار 2015-03

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